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There's been sizeable discussion during the literature not too long ago pertaining on the Bacterial Endotoxins Test, its significance and interpretation, and its comparison towards the USP rabbit take a look at.
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The specific mechanism of this phenomenon, termed endotoxin tolerance, is unfamiliar". Also, some scientific tests have revealed which the endotoxin from the Legionnaires' bacillus has a special spectrum of toxicity than the more typical gram-damaging organisms. Particularly the Legionnaires' endotoxin was not extremely pyrogenic (from the rabbit take a look at), but was incredibly Energetic from the LAL - 1,000 fold difference between the two checks. In this example, the rabbit examination is inadequate for figuring out the potency from the toxins existing.
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